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monitoring needed in Phase 3 Unknown long-term risks : No outcomes data

As the field increasingly embraces combination therapies and network-level interventions, revisiting these systems with modern tools may yield treatments that address not only caloric intake but also the behavioral and psychological dimensions of metabolic disease

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Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide (Lv et al., 2019)

Achieving this objective poses two specific challenges: Creating enough pharmaceutical manufacturing operations in the U.S