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Description
The sequence of the fusion protein Gly 8 Glu 22 Gly 36 -GLP-1 737 -(Gly 4 Ser) 3 Ala-Ala 234,235 Pro 228 -IgG 4 -Fc is modified in the N terminus of GLP-1 to protect against DPP-4 cleavage (Gly 8 ), and the IgG 4 Fc is modified to reduce interaction with high-affinity Fc receptors and avoid antibody-dependent cell-mediated cytotoxicity
"In more severe cases, an injectable collagen stimulator, such as poly-L-lactic acid (Lanluma), can be added," she explains
Differential Effects of Oxyntomodulin and GLP-1 on Glucose Metabolism
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doi: 10.1016/j.pharmthera.2006.11.007 52 BrandT
