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doi: 10.1097/MNH.0b013e328350313e

Administration of an estrogen receptor antagonist was sufficient to blunt the effects of the central GLP-1 agonist on food reward behavior in both men and women

Ozempic edges ahead for patients prioritizing maximum A1C reduction and weight loss, while Trulicity appeals to those wanting dosing flexibility and injection simplicity

Hence, modestly diminished GLP-1 action in diabetic subjects does not likely contribute to the defective glucose-stimulated glucagon suppression that remains a characteristic of diabetic subjects 3

42 Additionally, to evaluate whether baseline characteristics affected the findings, we conducted meta-regressions of potential effect modifiers, including the duration of type 2 diabetes, age, and background hypoglycaemic treatments