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Lifestyle integration, adherence, and follow-up

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While the absolute risk increase was modest, our findings point to an important potential adverse effect that clinicians should consider, especially in patients with predisposing factors for GERD

Medications called GLP-1s, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), are used to treat conditions such as type 2 diabetes and obesity.

Combining the therapeutic approaches of GLP-1 agonists (which target extrahepatic mechanisms for metabolic disorders) with resmetirom (which target intrahepatic mechanisms for MASH and liver fibrosis) seems like a promising strategy for addressing fat accumulation, inflammation, and fibrosis associated with MASH.