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They showed that organ bath studies identified a role of GLP-1R in the regulation of smooth muscle function by influencing the basal tone in colonic muscle strips and mediating relaxation of acetylcholine-induced phasic and tonic contractions in the colon

[DOI] [PubMed] [Google Scholar] MacLusky NJ, Cook S, Scrocchi L, Shin J, Kim J, Vaccarino F, Asa SL, Drucker DJ

Retraso del vaciamiento gstrico : Disminuyen la velocidad con que los alimentos salen del estmago, lo que contribuye a una absorcin ms lenta de nutrientes y una sensacin prolongada de saciedad

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Tirzepatide (GLP-1/GIP Dual Agonist) Pathway: Tirzepatide targets GLP-1 + GIP