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Description
It demonstrated to have a safety profile similar to GLP-1RA not increasing the risk of hypoglycemia ( In the SURPASS-2 study, TZP at the dose of 5, 10, and 15 mg were compared to the GLP-1RA semaglutide (1 mg once weekly) in patients not well controlled in therapy only with metformin ( 1c ( The SURPASS-3 study was started to study the efficacy and safety of TZP versus basal insulin degludec in diabetic patients inadequately controlled by metformin with or without an SGLT2-i for 52 weeks ( In the 52-week SURPASS-4 trial TZP was tested versus insulin glargine in diabetic adults and a high CV risk below not sufficient GC at baseline and in therapy with one to three oral glucose-lowering drugs (metformin, sulfonylurea, SGLT2-i)
Oprah in particular has been vocal over the years about never promoting weight loss products
Br J Pharmacol, 179:600-624
Age-related changes in intestinal function may also affect GLP-1 production, though evidence remains limited
In T2DM patients and obesity, there is no increased risk of pancreatitis
