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This publication was made possible by support from the IDSA Foundation to P.Z

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[1] [2] This contributes to reduced food intake and modest weight loss in many patients with type 2 diabetes

Interestingly, tirzepatide displays similar activity to native GIP at the GIP receptor, but has lower affinity and potency than GLP-1 at the GLP-1R, suggesting it favors GIPR signaling (Willard et al., 2020