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Depression-driven behaviors like consuming high-calorie, low-nutrient foods and reduced physical activity [87] contribute to weight gain and increased visceral fats, which are critical in developing IR

This is important for individuals taking semaglutide, as preserving muscle mass can improve metabolic rate and overall physical function

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While GLP-1 agonists primarily target appetite and gastric emptying, tirzepatide is studied for its additional GIP receptor effectsparticularly on adipose tissue metabolism and potentially enhanced insulin secretion