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For example, using a low-dose starting regimen (such as 1 milligram per week) and gradually titrating the dose can reduce the incidence of gastrointestinal reactions by 30%

Acid-Base Balance: Unlike other phosphate binders, Sevelamer does not contain calcium or aluminum, helping to maintain a healthier acid-base balance in the body

Nonetheless, the 111In is costly and has a significant radiation burden on patients

Findings from Phase 1 trials helped refine patient selection criteria for later trials, ensuring appropriate study populations

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