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Combining opioids with semaglutide increases constipation risk, so switching to non-opioid pain management whenever possible reduces complications

Fibrosis research One particularly interesting finding comes from research on semaglutide and fibrosis

Instead, the two groups recommend careful weighing of risks and benefits and discussion between the patient and their care team to make an informed decision

GLP-1 medications delay gastric emptying, so even though a patient may have fasted before surgery as usual, some food or liquid may remain

However, the combination of a magnitude of weight loss that has historically correlated with cardiovascular benefit, plus direct lipid and blood pressure effects, provides a biologically credible case that retatrutide may show cardiovascular event reduction in long-term trials