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Significant weight loss in obese/overweight people was demonstrated for liraglutide versus placebo in populations with and without T2D in the SCALE trials (Davies et al, 2015

It is widely known that inflammation is a common feature in metabolic diseases, spreading from peripheral tissue to the brain, thus resulting in cognitive dysfunctions (85)

Households with higher levels of income experience an even larger decline in spending by nearly 9% or $690 less annually

The Future: Multi-Agonist Era Tirzepatide Dual agonist: GLP-1 + GIP Produces: Exceptional HbA1c reduction Major weight loss Retatrutide Triple agonist: GLP-1 + GIP + Glucagon receptor Early trials demonstrated unprecedented weight loss results approaching bariatric surgery outcomes

An independent investigation found that the purities of some off-brand products were far less than labelled on packages, with some containing endotoxins suggesting microbial contamination (White 2024)