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In trials for knee OA (TRIUMPH1 OA basket and TRIUMPH4), the primary endpoint includes the average change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score, and key secondary endpoints include change in the WOMAC physical function subscale score and the percentage of participants with a 50% reduction in the WOMAC pain subscale score

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doi: 10.1007/s13679-023-00534-z 61 ColbergSRSigalRJYardleyJERiddellMCDunstanDWDempseyPCet al

Cholelithiasis was reported by 1.6% of semaglutide-treated patients and 0.7% of placebo-treated patients