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Nevertheless, GLP-1 RAs have gastrointestinal adverse effects such as abdominal pain, constipation, diarrhea, nausea, and vomiting [7]

A haemagglutinin (HA) signal peptide was added to the N-terminus of GLP-2R to increase the expression level

Eat cooked vegetables instead of raw to reduce fiber load while maintaining nutrients, she says

In these settings, glucose dysregulation, visceral adiposity, fatty liver, vascular inflammation, and chronic low-grade inflammation often reinforce one another, creating a cascade of metabolic stress that accelerates functional decline

Most clinicians recommend starting GLP-1 first, stabilizing through the dose escalation phase, and then adding carbohydrate restriction once medication effects are predictable