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Importantly, GLP-1 and glucagon act through structurally related receptors and both peptides exhibit similar amino acid N-terminal sequences, a domain essential for proper interaction with their receptors

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The MASLD read-through may appeal to hepatology stakeholders as the field pivots toward integrated metabolic-liver outcomes, but the commercial path likely runs through obesity first, where payers and regulators will demand clear, clinically meaningful weight loss and durability on top of safety
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She later switched to Wegovy