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A study by Stafeev et al
[DOI] [PubMed] [Google Scholar] 122.Sattar N, et al
Consistent with CD-1 mouse PK data, intact AMG 133 has a shorter mean t 1/2,z compared to total AMG 133 (207 h versus 292 h)
These nodes are not intrinsically pathological but may become clinically relevant when oxidative demand and substrate availability diverge
This rapid glucose lowering can also induce hypoxia, which may modulate the effect of GLP-1 RAs on retinal VEGF expression [100]
