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Seasonal stacking may work

Growing awareness of the benefits of GLP-1 RAs for weight management and cardiovascular health

The CREDENCE clinical trial evaluated the effects of canagliflozin 100 mg daily versus placebo in 4401 patients with T2DM and chronic kidney disease (CKD)

Importantly, the largest reductions in BMI were observed in the southern United States, which also reported the highest rates of GLP-1 RA dispensing claims (Rader et al., 2024), a geographic concordance that is consistent with a causal contribution of these pharmacotherapies to the observed population-level BMI decline

Standard protocols begin at 0.25 mg weekly, then step up to 0.5 mg, 1 mg, 1.7 mg, and potentially 2.4 mg based on your tolerance and weight loss goals