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We conducted a comprehensive search of MEDLINE, Embase, Scopus, and Cochrane CENTRAL, along with Google Scholar for additional internet sources, from their inception until December 2024 for randomized controlled trials of the effects of GLP-1 RAs on testosterone levels in men with functional hypogonadism

This view is supported by experiments in which conserved intramembranous polar residues in GLP-1R were mutated to alanine