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No increase in QTc was observed with either 25 mg or 200 mg empagliflozin

In a pooled analysis of the two monotherapy studies, the add-on to metformin study, and the add-on to pioglitazone study, the overall incidence of adverse reactions of hypoglycemia was 1.2% in patients treated with JANUVIA 100 mg and 0.9% in patients treated with placebo

Both activate the same receptors, so stacking them increases the risk of side effects without necessarily improving efficacy

Based on the binding modes and interaction analyses of the protein complex, interaction and non-interaction interfaces were delineated