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These drug interactions can affect how topiramate works, or they can cause mild or even serious side effects
From a mechanistic standpoint, both compounds activate the same GLP-1 and GIP receptors, which means concurrent administration would likely result in receptor saturation at those pathways without proportional additive benefit
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Poor insulin response is the number-one concern for diabetes patients, but insulin resistance resulting from obesity can also double down on testosterone suppression
Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A
