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Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults

Activity should support insulin sensitivity, muscle preservation, and cardiovascular health
doi: 10.1093/ecco-jcc/jjy004 5 AdolphTEMeyerMSchwrzlerJMayrLGrabherrFTilgH

Peripheral GLP-1/GLP-1RAs may also interact with the CNS indirectly by GLP-1R expressed on vagal afferent fibers, signaling via nodose ganglia (57) to the nucleus tractus solitarii within the brainstem

A recent network meta-analysis suggested that GLP-1R agonists were associated with significantly greater activity in decreasing liver fat content and improving cardiometabolic risk parameters in overweight or obese patients with NAFLD vs
