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Another important white space is represented by the emergence of comorbidity-driven positioning of oral obesity drugs, which allows marketing such medicines as treatment not only for weight loss but also for obesity associated with type 2 diabetes, cardiovascular risks, metabolic syndrome, and MASH

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Day et al., 2011

Only one of these exclusivities extended the duration of expected protection beyond existing patents (Byetta, 4.8 years)

PP, PYY, and NPY bind to G-protein coupled receptors Y 1 , Y 2 , Y 4 , Y 5 , and Y 6 , displaying promiscuity in their interactions with these receptors by virtue of their shared hair-pin-fold motif structure