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27 This emphasizes the need for robust and well-designed RCTs with a large population and longer duration to establish the extent of the role of GLP-1RAs in different subpopulations
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Pharmacological GLP-1RA Action Key Mechanistic Distinctions A comprehensive review published in Cell Metabolism reviewed circuits engaged by endogenous versus pharmacological GLP-1 action, highlighting key GLP-1R-positive cell types and pathways transducing metabolic and non-glycaemic GLP-1 signals

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