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The GLP-1RAs are also too large to cross the BBB, but they are engineered for longevity of drug effect so that it lasts in the blood for 12+ hours

TMS: Targeting the Brain Directly Transcranial magnetic stimulation has been FDA-approved for depression since 2008

When GLP-1 activity is balanced, you feel fuller for longer and experience more stable energy throughout the day

Rather than jumping to the maximum dose as quickly as the prescribing guidelines allow, consider staying at each dose level for a longer period
doi: 10.1016/j.ejphar.2012.12.012 143 McCleanPLJalewaJHolscherC
