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At Week 12, 61% to 64% of patients treated with tildrakizumab-asmn 100 mg achieved a PASI 75 and 55% to 58% achieved a PGA score of 0 or 1, a significant improvement over those treated with placebo (6% achieved PASI 75 and 4% to 7% achieved PGA 0 or 1)
The excessive proliferation of VSMCs could accelerate the deposition of atherosclerotic plaques in the vascular intima, leading to intimal thickening and vascular remodeling [102, 103]

The numbers on the scales are heading down, and then one morning there is noticeably more hair in the plughole than there used to be

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