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Two studies have shown that intense dietary and physical activity interventions 11,16 are less effective in children with MC4R deficiency, and weight reduction is harder to maintain in this group

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Tirzepatide was approved by the European Medicines Agency on 15 September 2022 and both the Food and Drug Administration and the Medicines and Healthcare products Regulatory Agency on 8 November 2023 [20] for weight management in adults with BMI 30 kg/m 2 or overweight (BMI 27 kg/m 2 to 20% weight loss vs

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