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Two studies have shown that intense dietary and physical activity interventions 11,16 are less effective in children with MC4R deficiency, and weight reduction is harder to maintain in this group

Tirzepatide was approved by the European Medicines Agency on 15 September 2022 and both the Food and Drug Administration and the Medicines and Healthcare products Regulatory Agency on 8 November 2023 [20] for weight management in adults with BMI 30 kg/m 2 or overweight (BMI 27 kg/m 2 to 20% weight loss vs

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