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Koehler (47) reported that GLP-1RAs may induce apoptosis by altering cell morphology in vitro , possibly by activating cAMP expression and inhibiting the activities of the signaling kinases glycogen synthase kinase 3 and ERK1/2, thereby inducing apoptosis and inhibiting the growth and survival of colon cancer cells

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[xi] Shaefer CF Jr, Kushner P, Aguilar R

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The gastrointestinal effects typically emerge during dose escalation and may diminish with continued use as physiologic adaptation occurs