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Beyond individual trials, a 2025 meta-analysis covering over 140,000 participants found tirzepatide yields a mean 4.23% greater weight loss than semaglutide (95% CI: 3.22 5.25

While Tirzepatide is commonly studied for dual receptor activity involving GLP-1 and GIP pathways, Retatrutide is often researched because of its additional receptor interactions

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