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Certain conditions can make GLP-1 treatment unsuitable - including a personal or family history of medullary thyroid carcinoma, pancreatitis, or multiple endocrine neoplasia type 2

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It's preventing cumulative glycogen depletion that leads to overtraining symptoms (persistent fatigue, elevated resting heart rate, declining pace at the same perceived effort)

Escalating before this point means you do not yet know what the current dose can do for you

In cases where grapefruit and medications cant mix, keep an eye out for the fruit and its juice on labels as anyone with an allergy or intolerance will tell you, these things can pop up in the most surprising of places