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Similarly, medications like Trulicity (dulaglutide) and Bydureon (exenatide extended-release) also offer weekly dosing, whereas shorter-acting alternatives like Byetta (exenatide immediate-release) typically need twice-daily injections

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So while these medications are very effective and have been studied in long trials, there is a substantial portion who won't achieve at least 5% weight loss

Collectively, these modifications prolong the half-life of semaglutide to approximately 1 week, or 165 hours (Lau et al., 2015)

Faster titration schedules Instead of increasing every four weeks, some providers use a three-week titration schedule: Faster titration is only appropriate under direct medical supervision