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Despite these findings, to our knowledge, there are no large population-based studies that have investigated the incidence of new-onset major cardiovascular events or clinically significant portal hypertension events in patients with MASLD who are receiving treatment with GLP-1 agonists for any indication
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efficacy estimand)
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Gastrointestinal disorders were experienced by 2.8% and 1.9% in the metformin, and 4.5% and 3.4% of subjects in the no-metformin subgroup receiving semaglutide and placebo, respectively
