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Efficacy studies have demonstrated this additive effect with metformin, sulfonylureas, and thiazolidinediones given in combination with saxagliptin and linagliptin

2021;12 doi: 10.3389/fendo.2021.721506

TABLE 3

[1] [2] Patients who experience pronounced nausea may prefer evening administration, while those who experience minimal gastrointestinal effects may prefer morning dosing to avoid any potential sleep disruption

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