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Effect of adjunctive simvastatin on depressive symptoms among adults with treatment-resistant depression: a randomized clinical trial

Adults can use Semaglutide with a body mass index (BMI) greater than or equal to 30, or if their BMI is 27 and they have at least one of the following weight-related conditions: high blood pressure, high cholesterol, or Type 2 diabetes

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Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al

Patients with slower caffeine clearance may experience more pronounced gastric stimulation when combined with semaglutide, while those with higher GLP-1R expression might tolerate caffeine better because their GI response is less pronounced
