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If you forget your injection on a warm counter overnight, kept it in an unheated garage, or accidentally froze it, err on the side of caution and request a fresh vial from your pharmacy

The relative risk was 0.76, actually trending slightly lower than placebo, though not statistically significant

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Under conditions of reduced portal insulin-to-glucagon ratio, lipolysis increases in adipose tissue and releases non-esterifed fatty acids which are converted to ketone bodies in the liver through mitochondrial beta oxidation and ketogenesis [25], resulting in a metabolic condition resembling a prolonged fast [26]