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Gut hormone adaptation also plays a role

So which indication is it

The ASCRS guidelines strongly recommend office-based treatments for patients with grade I and II hemorrhoids, and for some with grade III hemorrhoids.3 Ligating the apex of the hemorrhoidal cushion stops the arterial flow and causes the hemorrhoidal tissue to undergo necrosis (Figure 2)
Korner et al

Using it despite such an allergy can cause a severe reaction