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Tirzepatide was associated with dose-dependent reductions in body weight with a LSM difference of 5.8 kg (7.8% reduction), 8.5 kg (11.0% reduction), and 10.7 kg (13.9% reduction) for 5 mg, 10 mg, 15 mg, of tirzepatide, respectively, compared with 0.5 kg (0.7% reduction) for dulaglutide

Central nervous system-mediated appetite regulation represents a primary mechanism through which GLP-1 RAs induce weight reduction and subsequently improve hepatic steatosis

The federal Centers for Disease Control and Prevention estimates that 34% of North Carolina adults compared with 40% nationally are obese

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Researchers have found that this can induce the PTEN expression and, as a result, suppress downstream signaling (61)