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What is established is that its pharmacokinetic profile supports once-weekly dosing, achieved through a C20 fatty diacid moiety that binds to serum albumin the same strategy used by semaglutide and tirzepatide, both of which have half-lives of approximately 5-7 days

Intercepts NDA application was based on an interim analysis from their 18-month Phase 3 REGENERATE (ClinicalTrials.gov NCT02548351) clinical trial of Obeticholic acid with nearly 2500 NASH patients with fibrosis enrolled (Figure 1)

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Peripheral administration of exendin-4 or liraglutide increase circulating corticosterone in mice under basal conditions and also during a forced swimming test [818]
