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Progress has been compromised by two long-standing assumptions which have proved to be incorrect: (1) that delay in gastric emptying is the cause of symptoms, rather than being a marker of underlying dysfunction of gastroduodenal control mechanisms

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Additionally, most of the human evidence is derived from small randomized controlled trials and a number of observational studies with moderate risk of bias, which limits the certainty and generalizability of conclusions

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Visual acuity remained constant for 72.4% of patients, with 16.1% experiencing vision loss and 11.5% showing improvement

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A plausible explanation for the apparent advantage of GLP-1 RAs may involve their superior weight-loss efficacy relative to other antidiabetic drugs, particularly SGLT-2is, which themselves confer substantial CV benefits

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Disrupted digestive coordination The fundamental problem is timing disruption

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