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The absolute amount of lean mass lost is greater with GLP-1 medications primarily because the total weight loss achieved is substantially greater than with diet and exercise alone

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Combined with reduced appetite from GLP-1 and GIP activation, Retatrutide supports fat loss from multiple angles

doi: 10.1002/14651858.CD003987.pub5 238 Procter-GrayECobbKLCrawfordSLBachrachLKChirraASowersMet al