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Weight reduction that is substantial (14%) and rapid (over 3-4 mo) is associated with significant bone loss, 71 whereas more moderate and slower weight reduction may better preserve bone mass
Naltrexone/Bupropion (Contrave) Contrave combines two older medications that work on brain chemistry

Your provider determines whether semaglutide, tirzepatide, or a combination therapy suits your metabolic profile and weight loss goals