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93 In the randomized clinical trial STEP-HFpEF, patients who did not have T2D were assigned to either semaglutide 2.4 mg once weekly or placebo and followed for 52 weeks

Recently, chronic ICV infusion of a GLP-1R and glucagon receptor co-agonist has been shown to significantly decrease plasma and liver lipids in a cholesterol-fed hamster model of dyslipidemia

In summary, GLP-1 RAs, through weight loss and the reduction of pro-inflammatory cytokines [31, 33], could provide a complementary approach to standard therapies for HS, especially in patients with obesity [36]

In another systematic review that included individuals with T2D from 38 phase III or IV placebo-controlled randomized controlled trials with GLP-1RAbased therapy (16), nausea was reported in 19.3% of participants with active treatment versus 6.5% with placebo, and vomiting was reported in 7.6% of participants versus 2% with placebo

These effects can be mitigated through strength training, adequate protein and calories consumption, and a variety of minimally processed, nutrient-rich foods (Table 6) [292]