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Results CNR1 expression was upregulated in circulating CD4+ T cells from individuals at type 1 diabetes onset (6.9-fold higher vs healthy individuals) and in sorted islet beta cells from donors with type 1 diabetes (3.6-fold higher vs healthy counterparts)

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These findings align with results from the SURMOUNT-5 trial and an earlier real-world study from Truveta Research, with similar patterns observed across different study designs and patient populations