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Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings for pancreatitis, gallbladder disease, acute kidney injury, and hypoglycemia risk when used with insulin or sulfonylureas

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Physical activity enhances weight loss, improves insulin sensitivity, and helps maintain muscle mass

In clinical trials, individuals using tirzepatide for weight loss have seen an average weight reduction of 15% to 21% of their starting body weight over approximately 72 weeks