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Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]
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The American Association of Clinical Endocrinology has stated that it does not support routine microdosing and recommends adherence to FDA-approved dosing guidelines
