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Deficiency or dysregulation of GLP-1R has been linked to behavioral, mood, and cognitive disturbances [14, 15]

Lillys Oral GLP-1, Orforglipron, Demonstrated Statistically Significant Efficacy Results and a Safety Profile Consistent with Injectable GLP-1 Medicines in Successful Phase 3 Trial

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Importantly, payer reimbursement restrictions are probably in place because previous cost-effectiveness analyses of these medications have considered at least some measure of their glycaemic benefits [13, 14], while whether SGLT2is and GLP-1 RAs are cost-effective solely on the basis of their benefits on cardiovascular and kidney disease has never been studied as far as we are aware

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