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[DOI] [PMC free article] [PubMed] [Google Scholar] [182].Chiu M, Dillon A, Watson S (2016)

Semaglutide product development, clinical trial results, and regulatory submissions

Therapeutic considerations Maximal effect seen within 1015 days Adverse effects include allergic reactions, lacrimation, conjunctivitis and salivary gland pain Key prescribing point Iodide is used as a shortterm adjunct , and longterm use should be avoided due to loss of antithyroid efficacy
Nausea usually lessens as the body adjusts to the medication

Delayed complications include acute gastritis (stomach lining inflammation), acute kidney injury from dehydration, and in rare cases, acute pancreatitis with elevated lipase and amylase enzymes
