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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Aroda VR, Rosenstock J, Terauchi Y, et al
In particular, the inhibition of ASK-1 ameliorated MASH and improved fibrosis in some patients in a short-term clinical trial

Evidence of impaired autophagic flux, including accumulated autophagosomes and reduced lysosomal function, has also been observed in islets from human T2DM patients (45)

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Brand-name FDA-approved alternatives exist at dramatically higher prices and with insurance/prior-authorization barriers
