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The question becomes whether the additive appetite suppression helps or harms overall outcomes

After 48 weeks, the 4 mg retatrutide group led to weight reductions of more than 5%, 10%, and 15% in 92%, 75%, and 60% of participants, respectively

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Rapid weight loss produces facial volume changes (Ozempic face) and muscle loss, both partially preventable with slower titration and resistance training

This should include: HbA1c measurement to objectively assess glycaemic control Review of home blood glucose monitoring data (if applicable) Assessment for diabetes complications (retinopathy, nephropathy, neuropathy) Evaluation of cardiovascular risk factors Screening for other conditions affecting glucose control (such as thyroid dysfunction) if clinically indicated Consider medication intensification