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Interestingly, there are sex and sex differences in the prevalence of MASLD, and potential sex differences in innate immune cell types have been suggested to affect its development [17]
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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52
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