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UCP2 is a protein expressed in the inner mitochondrial membrane that primarily regulates ATP production

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6 To contextualize the mechanistic and translational barriers underlying these challenges, this section provides a comprehensive overview of CAR-T cell structure and generational evolution, summarizes clinical and preclinical efforts targeting NSCLC-specific antigens, and examines how PD-1 signaling within the TME compromises CAR-T cell efficacy