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The phosphorylated JAKs, especially JAK2, in turn stimulates the phosphorylation of three residues on the intracellular domain of LepRb (Tyr985, Tyr1077 and Tyr1138), and recruits distinct downstream signaling molecules to a leptin-specific signaling pathway to exhibit diverse physiological functions [84, 86]

Semaglutide, originally developed for type 2 diabetes management, has demonstrated significant weight loss results in clinical trials, with patients losing up to 15% of body weight over 68 weeks

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